PROMISE. Beyond frontiers.

Nutritional and regulatory roles of leucine in muscle growth and fat reduction.

The metabolic roles for L-leucine, an essential branched-chain amino acid (BCAA), go far beyond serving exclusively as a building block for de novo protein synthesis. Growing evidence shows that leucine regulates protein and lipid metabolism in animals. Specifically, leucine activates the mammalian target of rapamycin (mTOR) signaling pathway, including the 70 kDa ribosomal protein S6 kinase 1 ...

Erratum: The promise of neuroprotective agents in Parkinson's disease

Received: 27 March 2013; accepted: 15 April 2013; published online: 01 May 2013. Citation: Seidl SE and Potashkin JA (2013) Erratum: The promise of neuroprotective agents in Parkinson’s disease. Front. Neurosci. 7:69. doi: 10.3389/fnins. 2013.00069 This article was submitted to Frontiers in Neuropharmacology, a specialty of Frontiers in Neuroscience. Copyright © 2013 Seidl and Potashkin. This i...

The promise and challenge toward the clinical application of maspin in cancer.

Since the identification of the human maspin gene, a decade of extensive research revealed the promise of maspin both as a valuable molecular marker for the diagnosis and prognosis of many types of cancers, and as a tumor suppressor at the level of tumor growth, invasion, angiogenesis, metastasis, and tumor sensitivity to drug-induced apoptosis. This review is intended to summarize the consensu...

Free-Electron Lasers Push into New Frontiers

From the early days of the development of free-electron lasers (FELs) the promise of high power and short wavelengths has tantalized physicists and other scientists. Recent developments in accelerator technologies and some new discoveries about the physics of FELs have allowed researchers to push the performance of FELs into new frontiers of high power, short wavelength, and ultra-short pulses....

Beyond the Clinical Frontiers : A Psychiatrist Views Crows Behaviour